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Zocor belongs to HMG CoA reductase inhibitors (or statins) class of drugs and is used to lower cholesterol and triglycerides (types of fat) levels in blood. Zocor reduces “bad” cholesterol (LDL) and triglycerides levels in blood, while increasing levels of \"good\" cholesterol (HDL).Simvastatin is active ingredient present in Zocor tablets.
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Zocor competitively inhibit HMG CoA reductase activity, lowering cellular cholesterol concentration. This activates a cellular signaling cascade culminating in activation of sterol regulatory element binding protein (SREBP), a transcription factor that up-regulates expression of gene encoding LDL receptor. Thus, Zocor increases LDL receptor expression causing increased uptake of plasma LDL, and consequently decreases plasma LDL-cholesterol concentration.
Take Zocor as exactly prescribed by your health care professional because its dosage is based on your medical condition, age, response to treatment and other medications. Recommended starting dose of Zocor is 20mg - 40 mg per day, with usual dosage ranging from 5mg - 80mg per day. Zocor is an oral medication and usually recommended with or without meals and generally in evening.
Zocor is effective in lowering risk of heart attack, stroke and other heart complications in individuals with diabetes or coronary heart disease.
Less serious Zocor side effects include headache, cold symptoms, mild skin rash, insomnia, joint pain or stomach pain.
Serious side effects of Zocor include muscle pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice and dark colored urine.
