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Tamoxifen is a chemotherapy drug used in treatment of certain types of breast cancer in women and men which require estrogen for their growth. Tamoxifen also helps to prevent breast cancer in women belonging to high risk group and also to prevent reversal of disease.
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Tamoxifen (antiestrogen or Selective Estrogen Receptor Modulator (SERM)) acts by competitively binding to estrogen receptors present on tumors and other tissue targets, producing a nuclear complex which decreases synthesis of DNA, thereby inhibiting effects of estrogen. Tamoxifen is cytostatic (prevents (pre)cancerous cells from dividing) and not cytocidal (does not cause cell death).
Tamoxifen dosage should be taken as exactly prescribed by your health care professional because its dosage depends on severity of condition and medical history. Tamoxifen medication is usually recommended with a full glass of water and can be taken with or without your meals.
Common side effects of Tamoxifen that usually do not require medical attention include headache, mild nausea or vomiting, fatigue, hot flashes, mild hair loss, vaginal discharge and impotence (in men).
Serious side effects of Tamoxifen that require urgent medical help include sudden chest pain, new breast lumps, vision changes, changes in your menstrual cycle, numbness, pelvic pain or pressure, bloody vaginal discharge, swelling or skin rash.
Tamoxifen is found to be very effective medication for treatment of breast cancer that requires estrogen to grow.
